Anupama Narla Selected Research

Diamond-Blackfan Anemia (Anemia, Diamond Blackfan)

1/2022	Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond-Blackfan anemia.
1/2021	The active component of ginseng, ginsenoside Rb1, improves erythropoiesis in models of Diamond-Blackfan anemia by targeting Nemo-like kinase.
12/2020	L-leucine improves anemia and growth in patients with transfusion-dependent Diamond-Blackfan anemia: Results from a multicenter pilot phase I/II study from the Diamond-Blackfan Anemia Registry.
1/2020	Steroid resistance in Diamond Blackfan anemia associates with p57Kip2 dysregulation in erythroid progenitors.
10/2017	The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70.
1/2017	Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors.
12/2016	Erythrocyte adenosine deaminase levels are elevated in Diamond Blackfan anemia but not in the 5q- syndrome.
3/2014	The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders.
9/2012	L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.
8/2011	Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis.

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Anupama Narla Research Topics

Disease

13	Diamond-Blackfan Anemia (Anemia, Diamond Blackfan) 01/2022 - 04/2010
6	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2019 - 04/2010
5	Anemia 12/2020 - 09/2012
4	Chromosome 5q Deletion Syndrome 12/2016 - 04/2010
2	Macrocytic Anemia 01/2019 - 04/2010
2	Neoplasms (Cancer) 01/2014 - 10/2011
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020
1	Iron Overload 01/2018
1	Hematologic Diseases (Blood Diseases) 01/2017
1	Sickle Cell Anemia (Hemoglobin S Disease) 11/2016
1	Inflammation (Inflammations) 12/2014
1	Multiple Myeloma 01/2014
1	Bone Marrow Failure Disorders 08/2011
1	Mandibulofacial Dysostosis (Treacher Collins Syndrome) 04/2010
1	Cartilage-hair hypoplasia 04/2010
1	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 04/2010
1	Ectodermal Dysplasia (Aplasia Cutis Congenita) 01/2009

Drug/Important Bio-Agent (IBA)

5	Ribosomal Proteins (Ribosomal Protein)IBA 11/2014 - 04/2010
3	Leucine (L-Leucine)FDA Link 12/2020 - 09/2012
2	MicroRNAs (MicroRNA)IBA 01/2022 - 10/2011
2	Sirolimus (Rapamycin)FDA Link 01/2021 - 09/2012
2	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2020 - 08/2011
2	Pharmaceutical PreparationsIBA 01/2017 - 01/2014
2	DiamondIBA 11/2014 - 04/2010
2	Lenalidomide (CC 5013)FDA Link 01/2014 - 08/2011
2	Proteins (Proteins, Gene)FDA Link 09/2012 - 10/2011
1	Phosphotransferases (Kinase)IBA 01/2021
1	ginsenoside Rb1IBA 01/2021
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2020
1	enasidenibIBA 01/2020
1	SteroidsIBA 01/2020
1	Hemoglobins (Hemoglobin)IBA 01/2020
1	GlucocorticoidsIBA 01/2020
1	ribosomal protein S14IBA 01/2019
1	IronIBA 01/2018
1	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 10/2017
1	Adenosine DeaminaseIBA 12/2016
1	Messenger RNA (mRNA)IBA 11/2016
1	GlobinsIBA 11/2016
1	p38 Mitogen-Activated Protein KinasesIBA 12/2014
1	Etanercept (Enbrel)FDA Link 12/2014
1	Transcription Factors (Transcription Factor)IBA 01/2014
1	MorpholinosIBA 09/2012
1	Dexamethasone (Maxidex)FDA LinkGeneric 08/2011
1	NF-kappa B (NF-kB)IBA 01/2009

Therapy/Procedure

4	Therapeutics 12/2020 - 04/2011
2	Hematopoietic Stem Cell Transplantation 12/2020 - 01/2009
1	Splenectomy 01/2018
1	Erythrocyte Transfusion 08/2011